Effect of natural polymer on conventional and sustained release properties of indomethacin tablets

The aim of the present study was to evaluate seed flour of Vigna mungo (L.) Hepper or Black gram as binding, disintegration nature and sustained release matrix forming material in tablet formulation. The seeds of Vigna mungo swell and form gelatinous mass when it comes in contact with water due to its hydrophilic nature. Indomethacin (NSAIDS) was selected as a model drug because of its poor water solubility and short half life. FT -IR studies showed no evidence on interaction between indomethacin and Vigna mungo. Conventional /sustained release matrix tablets of indomethacin, was developed by using wet granulation technique. Compressed tablets were evaluated for pharmacopoeias tests and compared with marketed product. The kinetic studies showed that the release of drug from formulation CVF2 follows first order model and formulation SVF1 follows zero order model and anomalous diffusion and explained by Higuchi’s model. Selected conventional formulation CVF2 was carried out by anti-inflammatory activity by using plethysmometer. The selected formulations CVF2 and SVF1 was subjected to stability studies for three months at 45oC temperature with RH 75±5%, and showed stability with respect to release pattern.